Each consumer registers its own asyncio.Queue. When the value changes, the setter pushes (old, new) into every registered queue. Here's a simplified version that illustrates the core idea:
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Захарова заявила о энергетическом коллапсе в Европе02:46
Klenerman and Balasubramanian’s great insight was that template DNA could be sequenced by synthesizing a complementary strand of reversible terminators; basically, extending the chain one base at a time and determining the identity of each nucleotide by looking at the color of its fluorophore. In 1998, the pair started a company called Solexa to develop the technology.